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Article

Pharmacogenetic and clinical aspects of dihydropyrimidine dehydrogenase deficiency.

Annals of clinical biochemistry - 1 Jan 2003

van Kuilenburg André B P, De Abreu Ronney A, van Gennip Albert H

Abstract excerpt

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU). A deficiency of DPD is increasingly being recognized as the cause of an important pharmacogenetic syndrome. The importance of DPD deficiency in the aetiology of unexpected severe 5FU toxicity has been demonstrated by the fact that, in 39-59% of cases, decreased DPD activity could be detected in...

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Source

Identifiers

PMID: 12542909
DOI: 10.1258/000456303321016150

Genes

DPYD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pharmacogenetic and clinical aspects of dihydropyrimidine dehydrogenase deficiency.PMID 12542909Read ↗

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