Article
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2001
van Kuilenburg A B, Muller E W, Haasjes J, Meinsma R, Zoetekouw L, Waterham H R, Baas F, Richel D J, van Gennip A H
Abstract excerpt
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU), and it is suggested that patients with a partial deficiency of this enzyme are at risk from developing a severe 5FU-associated toxicity. In this study, we demonstrated that a lethal toxicity after a treatment with 5FU was attributable to a complete deficiency of DPD. Analysis of the DPD gene...
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