Evidence for a pseudo-autosomal locus for schizophrenia using the method of affected sibling pairs.

doi:10.1192/bjp.158.5.624

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Article

Evidence for a pseudo-autosomal locus for schizophrenia using the method of affected sibling pairs.

The British journal of psychiatry : the journal of mental science - 1 May 1991

Collinge J, Delisi L E, Boccio A, Johnstone E C, Lane A, Larkin C, Leach M, Lofthouse R, Owen F, Poulter M

Abstract excerpt

A susceptibility locus for schizophrenia in the 'pseudo-autosomal' region has been proposed on the basis of the reported excess of sex-chromosome aneuploidies (e.g. XXY and XXX) among patients with schizophrenia and the finding that schizophrenic sib-pairs are more often of the same than of the opposite sex. This hypothesis has been tested in 83 sibships with two or more siblings fulfilling Research Diagnostic...

Topics

Alleles
Chromosome Aberrations
Chromosome Disorders
Chromosome Mapping
DNA Probes
Diseases in Twins
Female
Gene Frequency
Genetic Linkage
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Pedigree

Phenotype

Psychiatric Status Rating Scales

Recombination, Genetic

Schizophrenia

Schizophrenic Psychology

Source

Open in PubMed

Identifiers

PMID: 1860017
DOI: 10.1192/bjp.158.5.624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1860017-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Evidence for a pseudo-autosomal locus for schizophrenia using the method of affected sibling pairs.PMID 1860017Read ↗

Evidence for a pseudoautosomal locus for schizophrenia. II: Replication of a non-random segregation of alleles at the DXYS14 locus.Semantic proximity Read ↗

No evidence for a pseudoautosomal locus for schizophrenia. Linkage analysis of multiply affected families.Semantic proximity Read ↗

Pseudoautosomal locus for schizophrenia excluded in 12 pedigrees.Semantic proximity Read ↗

An examination of linkage of schizophrenia and schizoaffective disorder to the pseudoautosomal region (Xp22.3)Semantic proximity Read ↗

Evidence for a pseudoautosomal locus for schizophrenia. I: A replication study using phenotype analysis.Semantic proximity Read ↗

Analysis of the pseudoautosomal X-linked gene SYBL1in bipolar affective disorder: description of a new candidate allele for psychiatric disorders.Semantic proximity Read ↗

Lack of linkage between schizophrenia and markers at the telomeric end of the pseudoautosomal region of the sex chromosomes.Semantic proximity Read ↗

Allele sharing for schizophrenia and schizo-affective disorder within a region of Homo sapiens specific XY homology.Semantic proximity Read ↗

Failure to establish linkage on the X chromosome in 301 families with schizophrenia or schizoaffective disorder.Semantic proximity Read ↗

A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes.Semantic proximity Read ↗

Male siblings with schizophrenia share alleles at the androgen receptor above chance expectation.Semantic proximity Read ↗

Pseudolinkage of the duplicate loci for supernatant aspartate aminotransferase in brook trout, Salvelinus fontinalis.Semantic proximity Read ↗

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