Article
Male siblings with schizophrenia share alleles at the androgen receptor above chance expectation.
American journal of medical genetics - 15 Oct 1993
Crow T J, Poulter M, Lofthouse R, Chen G, Shah T, Bass N, Morganti C, Vita A, Smith C, Boccio-Smith A
Abstract excerpt
In families that included two or more siblings with schizophrenia or schizo-affective disorder male-male pairs were found to share alleles at the androgen receptor (AR) gene (in Xq11.2-q12) above chance expectation (p < 0.003); female-female and mixed sex pairs showed no such tendency. The findings are compatible with X-Y linkage or with an X-linked contribution to liability in males.
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