Article
An examination of linkage of schizophrenia and schizoaffective disorder to the pseudoautosomal region (Xp22.3)
The British journal of psychiatry : the journal of mental science - 1 Feb 1994
Crow T J, Delisi L E, Lofthouse R, Poulter M, Lehner T, Bass N, Shah T, Walsh C, Boccio-Smith A, Shields G
Abstract excerpt
We investigated linkage between schizophrenia and the loci DXYS14, DXYS17, and MIC2 within the pseudoautosomal region in 85 families with two or more siblings suffering from schizophrenia or schizoaffective disorder. A maximum lod score of 2.44 was reached at MIC2, with a dominant model of inheri...
Topics
- Adult
- Alleles
- Chromosome Aberrations
- Chromosome Disorders
- Chromosome Mapping
- Cohort Studies
- DNA Probes
- Female
- Genes, Dominant
- Genes, Recessive
- Genetic Linkage
- Genetic Markers
- Humans
- Male
- Models, Genetic