Article
Genome-wide identification of haploinsufficiency in fission yeast.
Journal of microbiology and biotechnology - 1 Jun 2008
Baek Seung Tae, Han Sangjo, Nam Miyoung, Kim Young-Dae, Kim Lila, Lee Hyun-Jee, Heo Kyung-Sun, Lee Hyemi, Lee Minho, Park Song-Kyu, Maeng Pil Jae, Park Youngwoo, Lee Sunghou, Kim Dong-Uk, Kim Dongsup, Hoe Kwang-Lae
Abstract excerpt
Abnormal phenotypes resulting from haploinsufficiency (HI) are due to the loss of one allele. Recent studies in budding yeast have shown that HI originates from insufficient protein levels or from a stoichiometric imbalance between subunits of protein complexes. In humans, however, HI often involves transcription factors. Therefore, the species differences in HI and the molecular mechanisms of species-specific HI...
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