Article
Comparison of Virulence in Community‐Associated Methicillin‐Resistant<i>Staphylococcus aureus</i>Pulsotypes USA300 and USA400 in a Rat Model of Pneumonia
3 Jul 2008
Abstract excerpt
BACKGROUND: The predominant genetic background of community-associated methicillin-resistant Staphylococcus aureus has transitioned from USA400 to USA300 in most US communities. The explanation for this shift is unclear. We hypothesized that USA300 must be more pathogenic--specifically, that USA300 would have increased virulence when compared with USA400 in an animal model. METHODS: Rats were inoculated...
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