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Triplex Profiling of Functionally Distinct Chaperones (ERp29/PDI/BiP) Reveals Marked Heterogeneity of the Endoplasmic Reticulum Proteome in Cancer

4 Jul 2008

Abstract excerpt

The biomedical need for streamlined approaches to monitor proteome dynamics is growing rapidly. This study examined the ability of a knowledge-based triplex-profiling strategy (i.e., three functionally distinct chaperones, ERp29/PDI/BiP) to clarify uncertainties about how cancer affects the endoplasmic reticulum (ER) proteome. Investigating a wide range of samples at the tissue and cellular levels (>114 samples...

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PMID: 18598068
DOI: 10.1021/pr800126n

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