Article
The use of chelated radionuclide (samarium-153-ethylenediaminetetramethylenephosphonate) to modulate phenotype of tumor cells and enhance T cell-mediated killing.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2008
Chakraborty Mala, Wansley Elizabeth K, Carrasquillo Jorge A, Yu Sarah, Paik Chang H, Camphausen Kevin, Becker Michael D, Goeckeler William F, Schlom Jeffrey, Hodge James W
Abstract excerpt
PURPOSE: Exposing human tumor cells to sublethal doses of external beam radiation up-regulates expression of tumor antigen and accessory molecules, rendering tumor cells more susceptible to killing by antigen-specific CTLs. This study explored the possibility that exposure to palliative doses of a radiopharmaceutical agent could alter the phenotype of tumor cells to render them more susceptible to T cell-mediated...
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