Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Samarium-153-EDTMP (Quadramet®) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial.

Oncotarget - 18 Oct 2016

Heery Christopher R, Madan Ravi A, Stein Mark N, Stadler Walter M, Di Paola Robert S, Rauckhorst Myrna, Steinberg Seth M, Marté Jennifer L, Chen Clara C, Grenga Italia, Donahue Renee N, Jochems Caroline, Dahut William L, Schlom Jeffrey, Gulley James L

Abstract excerpt

PSA-TRICOM is a therapeutic vaccine in late stage clinical testing in metastatic castration-resistant prostate cancer (mCRPC). Samarium-153-ethylene diamine tetramethylene phosphonate (Sm-153-EDTMP; Quadramet®), a radiopharmaceutical, binds osteoblastic bone lesions and emits beta particles causing local tumor cell destruction. Preclinically, Sm-153-EDTMP alters tumor cell phenotype facilitating immune-mediated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Neoplasms
Share to Cancer Vaccines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organometallic Compounds

Share to Organophosphorus Compounds

Share to Osteoblasts

Share to Prostate-Specific Antigen

Share to Prostatic Neoplasms, Castration-Resistant

Share to Radiopharmaceuticals

Source

Open in PubMed Open full text

Identifiers

PMID: 27486817
DOI: 10.18632/oncotarget.10883
PMCID: PMC5340090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Samarium-153-EDTMP (Quadramet®) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial.PMID 27486817Read ↗

The use of chelated radionuclide (samarium-153-ethylenediaminetetramethylenephosphonate) to modulate phenotype of tumor cells and enhance T cell-mediated killing.Semantic proximity Read ↗

Development of a STEAP1-Targeted Prostate Cancer Specific Antibody Drug Conjugate Platform with Immunostimulatory PropertiesSemantic proximity Read ↗

CD46 targeted <sup>212</sup> Pb alpha particle radioimmunotherapy for prostate cancer treatmentSemantic proximity Read ↗

Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancerSemantic proximity Read ↗

Tumor-derived biomarkers beyond antigen expression enhance efficacy of CD276/B7H3 antibody-drug conjugate in metastatic prostate cancerSemantic proximity Read ↗

Pilot study of gadoxetate disodium-enhanced mri for localized and metastatic prostate cancers.Semantic proximity Read ↗

Multicenter Phase I Trial of a DNA Vaccine Encoding the Androgen Receptor Ligand-binding Domain (pTVG-AR, MVI-118) in Patients with Metastatic Prostate CancerSemantic proximity Read ↗

Clinical Translation of [68Ga]Ga-NOTA-anti-MMR-sdAb for PET/CT Imaging of Protumorigenic MacrophagesSemantic proximity Read ↗

Safety and exceptional immunogenicity of novel 5T4 viral vectored vaccination regimes in early stage prostate cancer: a phase I clinical trialSemantic proximity Read ↗

The Radiolabeling of [161Tb]-PSMA-617 by a Novel Radiolabeling Method and Preclinical Evaluation by In Vitro/In Vivo Methods.Semantic proximity Read ↗

Enhancing the anti-tumour activity of 177Lu-DOTA-octreotate radionuclide therapy in somatostatin receptor-2 expressing tumour models by targeting PARPSemantic proximity Read ↗

Feasibility and Safety of 68Ga-PSMA-11 PET/CT Using Cyclotron-Produced 68Ga in Patients with Prostate CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.