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Article

Loss of the SSeCKS/Gravin/AKAP12 gene results in prostatic hyperplasia.

Cancer research - 1 Jul 2008

Akakura Shin, Huang Changhui, Nelson Peter J, Foster Barbara, Gelman Irwin H

Abstract excerpt

SSeCKS/Gravin/AKAP12 (SSeCKS) is a kinase scaffolding protein that encodes metastasis-suppressor activity through the suppression of Src-mediated oncogenic signaling and vascular endothelial growth factor expression. SSeCKS expression is down-regulated in Src- and Ras-transformed fibroblasts, in human cancer cell lines and in several types of human cancer, including prostate. Normal human and mouse prostates...

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Source

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Identifiers

PMID: 18593908
DOI: 10.1158/0008-5472.CAN-07-5619
PMCID: PMC2839164

Genes

AKAP12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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