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Article

Impaired fitness of Mycobacterium africanum despite secretion of ESAT-6.

The Journal of infectious diseases - 15 Mar 2012

Bold Tyler D, Davis Daphne C, Penberthy Kristen K, Cox Laura M, Ernst Joel D, de Jong Bouke C

Abstract excerpt

BACKGROUND: When compared with Mycobacterium tuberculosis, individuals that live in the same household as an active case of smear-positive pulmonary tuberculosis exposed to M. africanum progress less frequently to active disease within 2 years. A putative ESX-1 secretion apparatus member, Rv3879c, is mutated in M. africanum, and individuals infected with M. africanum less frequently demonstrate T-cell responses...

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Identifiers

PMID: 22301632
DOI: 10.1093/infdis/jir883
PMCID: PMC3282571

Genes

CFP

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Source receipt: pubmed, retrieved 7 Sept 2026.

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