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Article

C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis.

Science (New York, N.Y.) - 15 Sept 2006

Champion Patricia A Digiuseppe, Stanley Sarah A, Champion Matthew M, Brown Eric J, Cox Jeffery S

Abstract excerpt

Mycobacterium tuberculosis uses the ESX-1/Snm system [early secreted antigen 6 kilodaltons (ESAT-6) system 1/secretion in mycobacteria] to deliver virulence factors into host macrophages during infection. Despite its essential role in virulence, the mechanism of ESX-1 secretion is unclear. We fou...

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Identifiers

PMID: 16973880
DOI: 10.1126/science.1131167

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CFP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16973880-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis.PMID 16973880Read ↗

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