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Article

Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia.

Anesthesiology - 1 Jul 2008

Nagele Peter, Zeugswetter Barbara, Wiener Caspar, Burger Hansjörg, Hüpfl Michael, Mittlböck Martina, Födinger Manuela

Abstract excerpt

BACKGROUND: Mutations in the methylenetetrahydrofolate reductase (MTHFR) gene (677C>T, 1298A>C) cause elevated plasma homocysteine concentrations and have been linked to fatal outcomes after nitrous oxide anesthesia. This study tested the hypothesis that patients with common MTHFR 677C>T or 1298A>C mutations develop higher plasma homocysteine concentrations after nitrous oxide anesthesia than wild-type patients....

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Source

Identifiers

PMID: 18580170
DOI: 10.1097/ALN.0b013e318178820b

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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