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Article

A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia.

Pharmacogenetics and genomics - 1 May 2009

Nagele Peter, Zeugswetter Barbara, Eberle Corinna, Hüpfl Michael, Mittlböck Martina, Födinger Manuela

Abstract excerpt

OBJECTIVES: Oxidation of vitamin B12 by nitrous oxide leads to the inactivation of methionine synthase resulting in elevated plasma total homocysteine concentrations. Methionine synthase reductase is the only human enzyme that is able to reverse the oxidation of vitamin B12, which also occurs nat...

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Source

Identifiers

PMID: 19339913
DOI: 10.1097/FPC.0b013e328328d54c

Genes

MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19339913-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia.PMID 19339913Read ↗

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