Exchanges of genomic domains between poliovirus and other cocirculating species C enteroviruses reveal a high degree of plasticity.

doi:10.1038/srep38831

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Article

Exchanges of genomic domains between poliovirus and other cocirculating species C enteroviruses reveal a high degree of plasticity.

Scientific reports - 13 Dec 2016

Bessaud Maël, Joffret Marie-Line, Blondel Bruno, Delpeyroux Francis

Abstract excerpt

The attenuated Sabin strains contained in the oral poliomyelitis vaccine are genetically unstable, and their circulation in poorly immunized populations can lead to the emergence of pathogenic circulating vaccine-derived polioviruses (cVDPVs). The recombinant nature of most cVDPV genomes and the...

Topics

Cell Line, Tumor
Enterovirus C, Human
Genome, Viral
Humans
Phenotype
Poliovirus
Recombination, Genetic
Virus Replication

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