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Detection of the Gua/Cyt-to-Cyt/Gua mutation in a Gua/Cyt-lined sequence using Zn2+-cyclen polyacrylamide gel electrophoresis.

Analytical biochemistry - 1 Sept 2008

Kinoshita Eiji, Kinoshita-Kikuta Emiko, Yoshimoto Miki, Koike Tohru

Abstract excerpt

We previously reported a method for the detection of single-nucleotide polymorphisms by polyacrylamide gel electrophoresis (PAGE) with an additive Zn(2+)-cyclen complex (cyclen=1,4,7,10-tetraazacyclododecane), called Zn(2+)-cyclen-PAGE. The method is based on the difference in mobility of mutant DNA (in the same length) in PAGE that is due to Zn(2+)-cyclen binding to thymine bases accompanying a total charge...

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PMID: 18570882
DOI: 10.1016/j.ab.2008.05.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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