Article
Detection of C:C mismatch base pair by fluorescence spectral change upon addition of silver (I) cation: toward the efficient analyses of single nucleotide polymorphism.
Nucleic acids symposium series (2004) - 1 Jan 2006
Torigoe Hidetaka, Kozasa Tetsuo, Ono Akira
Abstract excerpt
We have already found that silver (I) cation specifically binds to C:C mismatch base pair in heteroduplex, which increases the melting temperature of heteroduplex involving C:C mismatch base pair by about 4 degrees C. This result shows that addition of the metal cation is a promising strategy for the mismatch base pair detection in heteroduplex, but UV melting to determine the melting temperature is...
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