Article
Interleukin-10 promoter polymorphisms influence susceptibility to ulcerative colitis in a gender-specific manner.
Scandinavian journal of gastroenterology - 1 Jan 2008
Tedde Andrea, Laura Putignano Anna, Bagnoli Siro, Congregati Caterina, Milla Monica, Sorbi Sandro, Genuardi Maurizio, Papi Laura
Abstract excerpt
OBJECTIVE: Pathological evidence supports a potential role of the pro- and anti-inflammatory cytokine network in the pathogenesis of inflammatory bowel disease (IBD). Moreover, associated studies suggest a possible involvement of cytokine-related genes in IBD susceptibility. In this study, we evaluated the effect of the anti-inflammatory interleukin-10 (IL10) gene on ulcerative colitis (UC). MATERIAL AND METHODS:...
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