Article
Tumor environment dictates medulloblastoma cancer stem cell expression and invasive phenotype.
Molecular cancer research : MCR - 1 Jun 2008
Annabi Borhane, Rojas-Sutterlin Shanti, Laflamme Carl, Lachambre Marie-Paule, Rolland Yannève, Sartelet Hervé, Béliveau Richard
Abstract excerpt
The neural precursor surface marker CD133 is thought to be enriched in brain cancer stem cells and in radioresistant DAOY medulloblastoma-derived tumor cells. Given that membrane type-1 matrix metalloproteinase (MT1-MMP) expression is a hallmark of highly invasive, radioresistant, and hypoxic bra...
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