Article
The nuclear Dbf2-related kinase COT1 and the mitogen-activated protein kinases MAK1 and MAK2 genetically interact to regulate filamentous growth, hyphal fusion and sexual development in Neurospora crassa.
Genetics - 1 Jul 2008
Maerz Sabine, Ziv Carmit, Vogt Nico, Helmstaedt Kerstin, Cohen Nourit, Gorovits Rena, Yarden Oded, Seiler Stephan
Abstract excerpt
Ndr kinases, such as Neurospora crassa COT1, are important for cell differentiation and polar morphogenesis, yet their input signals as well as their integration into a cellular signaling context are still elusive. Here, we identify the cot-1 suppressor gul-4 as mak-2 and show that mutants of the gul-4/mak-2 mitogen-activated protein (MAP) kinase pathway suppress cot-1 phenotypes along with a concomitant...
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