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Article

Accumulation of specific sterol precursors targets a MAP kinase cascade mediating cell-cell recognition and fusion.

Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2016

Weichert Martin, Lichius Alexander, Priegnitz Bert-Ewald, Brandt Ulrike, Gottschalk Johannes, Nawrath Thorben, Groenhagen Ulrike, Read Nick D, Schulz Stefan, Fleißner André

Abstract excerpt

Sterols are vital components of eukaryotic cell membranes. Defects in sterol biosynthesis, which result in the accumulation of precursor molecules, are commonly associated with cellular disorders and disease. However, the effects of these sterol precursors on the metabolism, signaling, and behavior of cells are only poorly understood. In this study, we show that the accumulation of only ergosterol precursors with...

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Identifiers

PMID: 27708165
DOI: 10.1073/pnas.1610527113
PMCID: PMC5081648

Genes

MAK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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