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Gains and Amplifications of <i>c-myc, EGFR</i>, and <i>20.q13</i> Loci in the No Dysplasia–Dysplasia–Adenocarcinoma Sequence of Barrett's Esophagus

1 Jun 2008

Abstract excerpt

The progression of Barrett's esophagus to esophageal adenocarcinoma is often characterized by the accumulation of genetic abnormalities. The goal was to evaluate the copy number alterations of several oncogene loci, including 7p12 [epidermal growth factor receptor (EGFR)], 8q24 (c-myc), and 20q13 in the sequence of no dysplasia-dysplasia-adenocarcinoma of Barrett's esophagus. Fluorescence in situ hybridization...

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PMID: 18559552
DOI: 10.1158/1055-9965.epi-07-2734

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