Article
Functional evidence that Drosha overexpression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles.
The Journal of pathology - 1 Aug 2011
Muralidhar Balaji, Winder David, Murray Matthew, Palmer Roger, Barbosa-Morais Nuno, Saini Harpreet, Roberts Ian, Pett Mark, Coleman Nicholas
Abstract excerpt
Although gain of chromosome 5p is one of the most frequent DNA copy-number imbalances in cervical squamous cell carcinoma (SCC), the genes that drive its selection remain poorly understood. In a previous cross-sectional clinical study, we showed that the microRNA processor Drosha (located on chromosome 5p) demonstrates frequent copy-number gain and overexpression in cervical SCC, associated with altered microRNA...
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