Article
Rapid method for detection of mutations in the nucleophosmin gene in acute myeloid leukemia.
The Journal of molecular diagnostics : JMD - 1 Jul 2008
Laughlin Todd S, Becker Michael W, Liesveld Jane L, Mulford Deborah A, Abboud Camille N, Brown Patrick, Rothberg Paul G
Abstract excerpt
Mutations in exon 12 of the nucleophosmin gene (NPM1) that cause the encoded protein to abnormally relocate to the cytoplasm are found at diagnosis in about 50% of karyotypically normal acute myeloid leukemias and are associated with a more favorable outcome. We have devised a PCR-based assay for NPM1 exon 12 mutations using differential melting of an oligo probe labeled with a fluorescent dye. The nucleobase...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.