Article
Study by HPLC-MS of the interaction of platinum antitumor complexes with potato carboxypeptidase inhibitor (PCI).
Bioorganic & medicinal chemistry - 15 Jul 2008
Martínez Alberto, Moreno Virtudes, Sanglas Laura, de Llorens Rafael, Avilés Francesc X, Lorenzo Julia
Abstract excerpt
The interaction of the well-known antitumor drug cisplatin cis-[PtCl(2)(NH(3))(2)] and the compound trans-[PtCl(2)NH(3)(4-hydroxymethylpyridine)] with the small protein potato carboxypeptidase inhibitor (PCI) and a PCI mutant in which glycine-39 was substituted by methionine has been followed by HPLC/mass spectrometry. Our results showed that both Pt drugs were able to bind PCI through Met-39 and histidines in...
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