The sequence of the acidic repeat protein (<i>arp</i>) gene differentiates venereal from nonvenereal<i>Treponema pallidum</i>subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis

Abstract excerpt

Despite the completion of the Treponema pallidum genome project, only minor genetic differences have been found between the subspecies that cause venereal syphilis (ssp. pallidum) and the nonvenereal diseases yaws (ssp. pertenue) and bejel (ssp. endemicum). In this paper, we describe sequence variation in the arp gene which allows straightforward differentiation of ssp. pallidum from the nonvenereal subspecies....

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