Article
Quantitation of the JAK2V617F mutation in microdissected bone marrow trephines: equal mutational load in myeloid lineages and rare involvement of lymphoid cells.
The American journal of surgical pathology - 1 Jun 2008
Kremer Marcus, Horn Thomas, Koch Ina, Dechow Tobias, Gattenloehner Stefan, Pfeiffer Walter, Quintanilla-Martínez Leticia, Fend Falko
Abstract excerpt
The JAK2V617F mutation is an essential oncogenic event in Philadelphia negative chronic myeloproliferative disorders (Ph-cMPD). It is still unclear how a unique tyrosine kinase mutation can give rise to the broad clinical and morphologic spectrum of Ph-cMPD. One possible explanation could be differences in the JAK2V617F gene dosage, or different maturation stages on which myeloid lineages are affected by the...
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