Article
JAK2-V617F-mutated myeloproliferative neoplasms reveal different allele burden within hematopoietic cell lineages: a microdissection study of bone marrow trephine biopsies.
Virchows Archiv : an international journal of pathology - 1 Nov 2011
Kreft Andreas, Kindler Thomas, Springer Erik, Kirkpatrick Charles James
Abstract excerpt
The JAK2-V617F mutation is prevalent in almost all patients with polycythemia vera (PV) and about half of the cases of essential thrombocythaemia (ET) and primary myelofibrosis (PMF). A different allele burden in these entities has long been noticed, but little is known about its distribution among the neoplastic hematopoietic cell lineages within the bone marrow. We conducted a microdissection study of...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Biopsy
- Bone Marrow
- Cell Lineage
- Erythropoiesis
- Female
- Hematopoiesis
- Humans
- Janus Kinase 2
- Male
- Microdissection
- Middle Aged