Article
Perinucleolar compartment prevalence is a phenotypic pancancer marker of malignancy.
Cancer - 15 Aug 2008
Norton John T, Pollock Callie B, Wang Chen, Schink Julian C, Kim J Julie, Huang Sui
Abstract excerpt
BACKGROUND: The perinucleolar compartment (PNC) is a subnuclear structure localized at the nucleolar periphery. Previous studies using breast cancer as a model system demonstrated that PNC prevalence (the percentage of cells with 1 or more PNC) increased with disease progression and was associated with poor patient outcomes. METHODS: To evaluate the validity of developing PNC prevalence as a novel pancancer...
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