Article
Phenotype clustering of breast epithelial cells in confocal images based on nuclear protein distribution analysis.
BMC cell biology - 10 Jul 2007
Long Fuhui, Peng Hanchuan, Sudar Damir, Lelièvre Sophie A, Knowles David W
Abstract excerpt
BACKGROUND: The distribution of chromatin-associated proteins plays a key role in directing nuclear function. Previously, we developed an image-based method to quantify the nuclear distributions of proteins and showed that these distributions depended on the phenotype of human mammary epithelial cells. Here we describe a method that creates a hierarchical tree of the given cell phenotypes and calculates the...
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