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Article

The first functional study of <i>MLH3</i> mutations found in cancer patients

2 Jun 2008

Abstract excerpt

The MLH3 gene is one of the five mismatch repair (MMR) genes associated with hereditary nonpolyposis colorectal cancer (HNPCC). Eighteen different inherited MLH3 mutations have been reported as pathogenic in an international mutation database. In several cases, a mutation was found in a patient without a family history suggestive of inherited cancer susceptibility. In some cases, a similar mutation was also found...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18521850
DOI: 10.1002/gcc.20581

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