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Article

Least dissipation cost as a design principle for robustness and function of cellular networks.

Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Mar 2008

Han Bo, Wang Jin

Abstract excerpt

From a study of the budding yeast cell cycle, we found that the cellular network evolves to have the least cost for realizing its biological function. We quantify the cost in terms of the dissipation or heat loss characterized through the steady-state properties: the underlying landscape and the associated flux. We found that the dissipation cost is intimately related to the stability and robustness of the...

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PMID: 18517437
DOI: 10.1103/PhysRevE.77.031922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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