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Article

Membrane protein SMP-1 is required for normal flagellum function in Leishmania.

Journal of cell science - 15 Feb 2010

Tull Dedreia, Naderer Thomas, Spurck Timothy, Mertens Haydyn D T, Heng Joanne, McFadden Geoffrey I, Gooley Paul R, McConville Malcolm J

Abstract excerpt

Eukaryotic flagella and cilia are surrounded by a membrane that is continuous with, but distinct from, the rest of the plasma membrane. In Leishmania parasites, the inner leaflet of the flagellar membrane is coated with the acylated membrane protein, SMP-1. Here, we provide evidence that SMP-1 stabilizes the flagellar membrane and is required for flagella elongation and function. The expression and flagella...

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Identifiers

PMID: 20086045
DOI: 10.1242/jcs.059097

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