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Disturbed retinoid metabolism upon loss of <i>rlbp1a</i> impairs cone function and leads to subretinal lipid deposits and photoreceptor degeneration in the zebrafish retina

2021-06-18

Abstract excerpt

The RLBP1 gene encodes the 36 kDa cellular retinaldehyde binding protein, CRALBP, a soluble retinoid carrier, in the visual cycle of the eyes. Mutations in RLBP1 are associated with recessively inherited clinical phenotypes, including Bothnia dystrophy, retinitis pigmentosa, retinitis punctata albescens, fundus albipunctatus, and Newfoundland rod-cone dystrophy. However, the etiology of these retinal disorders i...

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Literature Corpus work
e046eaab-64bd-5f95-bc8d-fcb974d6ed86
DOI
10.1101/2021.06.18.448986
Open publication

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Disturbed retinoid metabolism upon loss of <i>rlbp1a</i> impairs cone function and leads to subretinal lipid deposits and photoreceptor degeneration in the zebrafish retinaDOI 10.1101/2021.06.18.448986
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