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Article

High frequency of copy‐neutral LOH in <i>MUTYH</i>‐associated polyposis carcinomas

26 Apr 2008

Abstract excerpt

Genetic instability is known to drive colorectal carcinogenesis. Generally, a distinction is made between two types of genetic instability: chromosomal instability (CIN) and microsatellite instability (MIN or MSI). Most CIN tumours are aneuploid, whereas MSI tumours are considered near-diploid. However, for MUTYH-associated polyposis (MAP) the genetic instability involved in the carcinogenesis remains unclear, as...

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PMID: 18506705
DOI: 10.1002/path.2375

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