Article
Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV.
The Journal of infectious diseases - 15 Jul 2008
Mizukoshi Eishiro, Eisenbach Christoph, Edlin Brian R, Newton Kimberly P, Raghuraman Sukanya, Weiler-Normann Christina, Tobler Leslie H, Busch Michael P, Carrington Mary, McKeating Jane A, O'Brien Thomas R, Rehermann Barbara
Abstract excerpt
BACKGROUND: Injection drug users (IDUs) who successfully clear hepatitis C virus (HCV) have a reduced risk of developing chronic reinfection, despite their continuing exposure to the virus. To identify immunological correlates for this apparent protection, we studied HCV-specific immune responses in long-term IDUs (duration, >10 years). METHODS: HCV-specific T cell responses were assessed in proliferation,...
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