Article
Hepatitis C virus Broadly Neutralizing Monoclonal Antibodies Isolated 25 Years after Spontaneous Clearance.
PloS one - 1 Jan 2016
Merat Sabrina J, Molenkamp Richard, Wagner Koen, Koekkoek Sylvie M, van de Berg Dorien, Yasuda Etsuko, Böhne Martino, Claassen Yvonne B, Grady Bart P, Prins Maria, Bakker Arjen Q, de Jong Menno D, Spits Hergen, Schinkel Janke, Beaumont Tim
Abstract excerpt
Hepatitis C virus (HCV) is world-wide a major cause of liver related morbidity and mortality. No vaccine is available to prevent HCV infection. To design an effective vaccine, understanding immunity against HCV is necessary. The memory B cell repertoire was characterized from an intravenous drug user who spontaneously cleared HCV infection 25 years ago. CD27+IgG+ memory B cells were immortalized using BCL6 and...
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