Article
A transformation-incompetent, nuclear antigen 2-deleted Epstein-Barr virus associated with replicative infection.
The Journal of infectious diseases - 1 May 1991
Sixbey J W, Shirley P, Sloas M, Raab-Traub N, Israele V
Abstract excerpt
Epstein-Barr virus (EBV) obtained directly from the oropharynx was used to detect viral DNA deleted for the EBV nuclear antigen 2 (EBNA2)-encoding gene that is essential for lymphocyte transformation. By polymerase chain reaction analysis, the deletion was found in virus from 5 of 33 healthy adul...
Topics
- Antigens, Viral
- Base Sequence
- Cell Line
- Cell Nucleus
- Cell Transformation, Viral
- Chromosome Deletion
- DNA, Viral
- Epstein-Barr Virus Nuclear Antigens
- Herpesviridae Infections
- Herpesvirus 4, Human
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Oropharynx
- Polymerase Chain Reaction
- Virus Replication