Article
A transformation-incompetent, nuclear antigen 2-deleted Epstein-Barr virus associated with replicative infection.
The Journal of infectious diseases - 1 May 1991
Sixbey J W, Shirley P, Sloas M, Raab-Traub N, Israele V
Abstract excerpt
Epstein-Barr virus (EBV) obtained directly from the oropharynx was used to detect viral DNA deleted for the EBV nuclear antigen 2 (EBNA2)-encoding gene that is essential for lymphocyte transformation. By polymerase chain reaction analysis, the deletion was found in virus from 5 of 33 healthy adult donors and 11 of 12 patients with concurrent human immunodeficiency virus infection. Lymphoblastoid cell lines that...
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