Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide linkage scan in fuchs endothelial corneal dystrophy.

Investigative ophthalmology & visual science - 1 Mar 2009

Afshari Natalie A, Li Yi-Ju, Pericak-Vance Margaret A, Gregory Simon, Klintworth Gordon K

Abstract excerpt

PURPOSE: To perform a genome-wide linkage screen with a single-nucleotide polymorphism (SNP) linkage panel to identify regions of genetic linkage in Fuchs endothelial corneal dystrophy (FECD) and to analyze affected individuals for mutations in the COL8A2 gene. METHODS: Ninety-two individuals from 22 families with FECD were identified from our multiplex FECD family cohort. A genome-wide linkage scan was performed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 15
Share to Fuchs' Endothelial Dystrophy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Genetic Markers

Share to Genotype

Share to Lod Score

Share to Pedigree

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 18502986
DOI: 10.1167/iovs.08-1839
PMCID: PMC2712757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide linkage scan in fuchs endothelial corneal dystrophy.PMID 18502986Read ↗

A multicenter study to map genes for Fuchs endothelial corneal dystrophy: baseline characteristics and heritability.Semantic proximity Read ↗

Genome-Wide Association Study of Corneal Dystrophy Uncovers Novel Risk Loci and Enables Improved Polygenic Prediction of Fuchs Endothelial Corneal Dystrophy.Semantic proximity Read ↗

Linkage of a mild late-onset phenotype of Fuchs corneal dystrophy to a novel locus at 5q33.1-q35.2.Semantic proximity Read ↗

Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophySemantic proximity Read ↗

A common locus for late-onset Fuchs corneal dystrophy maps to 18q21.2-q21.32.Semantic proximity Read ↗

The genetics of Fuchs’ corneal dystrophySemantic proximity Read ↗

Genetic and Demographic Determinants of Fuchs Endothelial Corneal Dystrophy Risk and SeveritySemantic proximity Read ↗

Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy.Semantic proximity Read ↗

Q455V mutation in COL8A2 is associated with Fuchs' corneal dystrophy in Korean patients.Semantic proximity Read ↗

From Genes to Disease: Reassessing LOXHD1 and AGBL1's Contribution to Fuchs' Dystrophy.Semantic proximity Read ↗

No pathogenic mutations identified in the COL8A1 and COL8A2 genes in familial Fuchs corneal dystrophy.Semantic proximity Read ↗

Genetic screen of African Americans with Fuchs endothelial corneal dystrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.