Article
A common locus for late-onset Fuchs corneal dystrophy maps to 18q21.2-q21.32.
Investigative ophthalmology & visual science - 1 Sept 2006
Sundin Olof H, Broman Karl W, Chang Howard H, Vito Elizabeth C L, Stark Walter J, Gottsch John D
Abstract excerpt
PURPOSE: To identify the genetic basis of late-onset Fuchs corneal dystrophy (FCD). METHODS: Phenotypes and genotypes at 1107 short tandem repeat polymorphism markers were obtained for 43 affected and 33 unaffected individuals in three large families. Two-point genetic linkage analysis was performed with MLINK and multipoint linkage with SimWalk 2.89. RESULTS: In each family, the most significant cluster of...
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