Article
Cyclooxygenase-2 induces genomic instability, BCL2 expression, doxorubicin resistance, and altered cancer-initiating cell phenotype in MCF7 breast cancer cells.
The Journal of surgical research - 15 Jun 2008
Singh Balraj, Cook Kendra R, Vincent Laura, Hall Carol S, Berry Jacob A, Multani Asha S, Lucci Anthony
Abstract excerpt
INTRODUCTION: Cyclooxygenase (COX2) expression in primary breast cancer correlates with a worse prognosis. We reported previously that COX2 expression in MCF10A breast epithelial cells of basal subtype induces genomic instability. To understand the role of COX2 in estrogen receptor-positive (non-basal) breast cancer, we transfected the MCF7 cell line with COX2 and analyzed its chromosomal profile, BCL2 protein...
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