Article
Characterization of collagenous matrix assembly in a chondrocyte model system.
Journal of biomedical materials research. Part A - 1 Jul 2009
Yingst Sorcha, Bloxham Kaci, Warner Lisa R, Brown Raquel J, Cole Jennifer, Kenoyer Linda, Knowlton William B, Oxford Julia Thom
Abstract excerpt
Collagen is a major component of the newly synthesized pericellular microenvironment of chondrocytes. Collagen types II, IX, and XI are synthesized and assembled into higher ordered complexes by a mechanism in which type XI collagen plays a role in nucleation of new fibrils, and in limiting fibril diameter. This study utilizes a cell line derived from the Swarm rat chondrosarcoma that allows the accumulation and...
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