Article
Numerous transitions in human parainfluenza virus 3 RNA recovered from persistently infected cells.
Virology - 1 Apr 1991
Murphy D G, Dimock K, Kang C Y
Abstract excerpt
The nucleotide sequences at the 3'-termini of human parainfluenza virus 3 (HPIV3) genomic RNAs recovered from two lines of persistently infected LLC-MK2 cells were determined following PCR amplification. After 29 months of persistence the 3'-end of the HPIV3 genome was found to be highly mutated. Interestingly, the only types of nucleotide changes observed were U to C and A to G transitions. Both U to C and A to...
Topics
- Base Sequence
- Cell Line
- Genes, Viral
- Humans
- Molecular Sequence Data
- Mutation
- Paramyxoviridae Infections
- Polymerase Chain Reaction
- RNA, Viral
- Respirovirus