Article
Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis.
BMC bioinformatics - 20 May 2008
Biswas Shameek, Storey John D, Akey Joshua M
Abstract excerpt
BACKGROUND: The combination of gene expression profiling with linkage analysis has become a powerful paradigm for mapping gene expression quantitative trait loci (eQTL). To date, most studies have searched for eQTL by analyzing gene expression traits one at a time. As thousands of expression traits are typically analyzed, this can reduce power because of the need to correct for the number of hypothesis tests...
Topics
- Chromosome Mapping
- Gene Expression
- Gene Expression Profiling
- Gene Expression Regulation
- Genetic Variation
- Principal Component Analysis
- Quantitative Trait Loci