Article
Polymorphisms in the leptin (rs7799039) gene are associated with an increased risk of excessive gestational weight gain but not with leptin concentration during pregnancy.
Nutrition research (New York, N.Y.) - 1 Nov 2017
Martins Maisa Cruz, Trujillo Janet, Farias Dayana Rodrigues, Kac Gilberto
Abstract excerpt
Single nucleotide polymorphisms (SNPs) in leptin (LEP) and leptin receptor (LEPR) have been shown to be linked to obesity-related metabolic markers and phenotype. Therefore, we hypothesized that the LEP-rs7799039 and LEPR-rs1137101 SNPs are related to the risk of pre-pregnancy overweight/obesity (body mass index ≥25 kg/m2) as well as to excessive gestational weight gain (GWG) and high concentrations of leptin...
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