Tissue-specific expression of p53 in transgenic mice is regulated by intron sequences.

doi:10.1002/mc.2940040103

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Article

Tissue-specific expression of p53 in transgenic mice is regulated by intron sequences.

Molecular carcinogenesis - 1 Jan 1991

Lozano G, Levine A J

Abstract excerpt

Transgenic mice were produced harboring the p53 murine cDNA clone regulated by the SV40 enhancer-promoter region 5' to the cDNA and the small t antigen splice sites, and poly(A) addition signals 3' to the cDNA. This construction was not expressed in these mice. The presence of several murine p53...

Topics

Animals
Enhancer Elements, Genetic
Gene Expression Regulation, Neoplastic
Introns
Mice
Mice, Transgenic
Mutation
Neoplasm Proteins
Promoter Regions, Genetic
RNA, Messenger
Simian virus 40
Tumor Suppressor Protein p53

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