Article
Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis.
FEMS microbiology letters - 16 Feb 2004
Malhotra Vandana, Sharma Deepak, Ramanathan V D, Shakila H, Saini Deepak K, Chakravorty Soumitesh, Das Taposh K, Li Qing, Silver Richard F, Narayanan P R, Tyagi Jaya Sivaswami
Abstract excerpt
The devR-devS two-component system of Mycobacterium tuberculosis was identified earlier and partially characterized in our laboratory. A devR::kan mutant of M. tuberculosis was constructed by allelic exchange. The devR mutant strain showed reduced cell-to-cell adherence in comparison to the parental strain in laboratory culture media. This phenotype was reversed on complementation with a wild-type copy of devR....
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