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Article

Crystal structures of human 108V and 108M catechol O-methyltransferase.

Journal of molecular biology - 27 Jun 2008

Rutherford K, Le Trong I, Stenkamp R E, Parson W W

Abstract excerpt

Catechol O-methyltransferase (COMT) plays important roles in the metabolism of catecholamine neurotransmitters and catechol estrogens. The development of COMT inhibitors for use in the treatment of Parkinson's disease has been aided by crystallographic structures of the rat enzyme. However, the h...

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Source

Identifiers

PMID: 18486144
DOI: 10.1016/j.jmb.2008.04.040

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18486144-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Crystal structures of human 108V and 108M catechol O-methyltransferase.PMID 18486144Read ↗

The 108M polymorph of human catechol O-methyltransferase is prone to deformation at physiological temperatures.Semantic proximity Read ↗

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Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol O-methyltransferase reaction.Semantic proximity Read ↗

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Catechol-O-methyltransferase: effects of the val108met polymorphism on protein turnover in human cells.Semantic proximity Read ↗

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