Article
Expression of the human papillomavirus E7 oncogene during cell transformation is sufficient to induce susceptibility to lysis by activated macrophages.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1991
Banks L, Moreau F, Vousden K, Pim D, Matlashewski G
Abstract excerpt
Human papillomaviruses (HPV), and in particular HPV type 16, are etiologic agents in the development of cervical cancer, which is the second most common form of cancer in women worldwide. Mammalian cells are susceptible to transformation in vitro by the E6 and E7 oncogenes derived from the HPV-16...
Topics
- Amino Acid Sequence
- Animals
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Cells, Cultured
- Cytotoxicity, Immunologic
- Macrophages
- Molecular Sequence Data
- Mutation
- Oncogene Proteins, Viral
- Oncogenes
- Papillomaviridae
- Papillomavirus E7 Proteins
- Retinoblastoma Protein