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Article

Expression of the human papillomavirus E7 oncogene during cell transformation is sufficient to induce susceptibility to lysis by activated macrophages.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1991

Banks L, Moreau F, Vousden K, Pim D, Matlashewski G

Abstract excerpt

Human papillomaviruses (HPV), and in particular HPV type 16, are etiologic agents in the development of cervical cancer, which is the second most common form of cancer in women worldwide. Mammalian cells are susceptible to transformation in vitro by the E6 and E7 oncogenes derived from the HPV-16 genome. NIH-3T3 cells transfected with the HPV-16 E7 oncogene were found to exhibit cytolytic susceptibility to...

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PMID: 1848576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of the human papillomavirus E7 oncogene during cell transformation is sufficient to induce susceptibility to lysis by activated macrophages.PMID 1848576Read ↗

Molecular mechanisms underlying human papillomavirus E6 and E7 oncoprotein-induced cell transformationSemantic proximity Read ↗

Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation.Semantic proximity Read ↗

Expression of the human papillomavirus type 16 E7 oncoprotein induces an autophagy-related process and sensitizes normal human keratinocytes to cell death in response to growth factor deprivationSemantic proximity Read ↗

Inactivation of the RB1 and PTPN14 tumor suppressors cooperatively enables the carcinogenic activity of the human papillomavirus E7 oncoproteinSemantic proximity Read ↗

The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosisSemantic proximity Read ↗

Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells.Semantic proximity Read ↗

Mutations of the human papillomavirus type 16 E7 gene that affect transformation, transactivation and phosphorylation by the E7 protein.Semantic proximity Read ↗

Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells.Semantic proximity Read ↗

Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformationSemantic proximity Read ↗

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cellsSemantic proximity Read ↗

Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression.Semantic proximity Read ↗

[Transformation of immortalized rat embryonic fibroblasts by the E7 gene of human type 16 papillomavirus].Semantic proximity Read ↗

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